Pathogenic, slow-growing Mycobacterium tuberculosis and other Mycobacterium tuberculosis complex (MTBC) species include the pe/ppe genes. In the pathogen-host connection, these genes are crucial. Despite the fact that the activities of most PE/PPE family proteins are unknown, mounting evidence shows they play a role in M. tuberculosis infection. The role of PE/PPE proteins, which are thought to be involved in the ESX system's action, is investigated. During complicated host-pathogen processes, we also discuss how PE/ PPE proteins are involved in host-pathogen interactions, immune response regulation, and cell fate determination. Finally, we discuss future PE/PPE protein research priorities as well as how present information might be used to develop more accurate diagnostics and vaccines for worldwide TB control. The pe and ppe genes, which are thought to be critical in TB pathogenesis, are only found in mycobacteria. However, nothing is known about how these genes' expression is regulated. Understanding the regulatory control of genes present only in mycobacteria, such as the pe and ppe gene families, might help researchers figure out why the illness is so effective. A transposon mutagenesis method was employed to better understand pe and ppe control. Rv1403c, a previously unknown transcriptional regulator, was discovered as a consequence of this study.