Advances in Systems BiologyAuthor: Lee K. Opresko, Julie M. Gephart, Michaela B. Mann Published by Springer US ISBN: 978-1-4613-4695-1 DOI: 10.1007/978-1-4419-8861-4Table of Contents:Introduction High-Throughput Techniques for Analyzing Complex Bacterial Communities A Systems Approach to Discovering Signaling and Regulatory Pathways —or, how to digest large interaction networks into relevant pieces Genome Function—A Virus-World View Ubiquitin-Mediated Proteolysis: An Ideal Pathway for Systems Biology Analysis Conformational Switching in Muscle The Intricate Workings of a Bacterial Epigenetic Switch Yeast Signal Transduction: Regulation and Interface with Cell Biology, Softcover reprint of the hardcover 1st edition originally published by Kluwer in 2004, Includes bibliographical references and index, This book is based on the proceedings of the inaugural symposium "Northwest Symposium for Systems Biology". Particular focus is on identifying current breakthrough technologies and their application to important model systems. By integrating computational sciences, high-throughput technologies and quantitative biology, this book will advance the understanding of not just the function of individual genes, proteins and smaller molecules like hormones, but also how all of these molecules interact within a cell. This volume will be a collection of presentations on four topics that comprise the scope of the Genomes to Life project recently announced by the Department of Energy. They are four aspects of a system biology approach to understanding microbial communities. These topics include complex microbial systems, gene regulatory networks, molecular machines/ multiprotein complexes and computational techniques, 1. Introduction -- Complex Microbial Systems -- 2. High-Throughout Techniques for Analyzing Complex Bacterial Communities -- Computational Methods -- 3. A Systems Approach to Discovering Signaling and Regulatory Pathways -- or how to digest large interaction networks into relevant pieces -- 4. Genome Function -- a virus-world view -- Molecular Machines: Multiprotein Complexes -- 5. Intracellular Proteolysis and Proteasomes -- 6. Conformational Switching in Muscle -- Gene Regulatory Networks -- 7. The Intricate Workings of a Bacterial Epigenetic Switch -- 8. Yeast Signal Transduction: Regulation and Interface with Cell Biology