Drug Toxicity in Embryonic Development II: Advances in Understanding Mechanisms of Birth Defects: Mechanistic Understanding of Human Developmental ToxicantsAuthor: Robert J. Kavlock Ph.D., George P. Daston Ph.D. Published by Springer Berlin Heidelberg ISBN: 978-3-642-64409-2 DOI: 10.1007/978-3-642-60447-8Table of Contents:Retinoids Peculiarities and Possible Mode of Actions of Thalidomide Anticonvulsant Drugs: Mechanisms and Pathogenesis of Teratogenicity Cardiovascular Active Drugs Anticoagulants Antiviral Agents Angiotensin-Converting Enzyme Inhibitor Fetopathy Anesthetics Alcohols: Ethanol and Methanol Developmental Toxicity of Dioxin: Searching for the Cellular and Molecular Basis of Morphological Responses Endocrine Disruptors: Effects on Sex Steroid Hormone Receptors and Sex Development, The prevention of birth defects in the human populations caused by exogenous chemicals is a goal of both primary care providers, drug developers, experimental teratologists, and risk assessors. This two-volume work provides a state-of- the-science assessment of how embryos accomplish the feat of morphogenesis at the molecular and cellular level, the key biochemical processes that drive morphogenesis and which are thus at risk to disruption, and the mechanisms of action by which known human teratogens exert their unwanted effects. These volumes provide the first comprehensive compilation of material focused on the understanding of the mechanism of action of chemicals which cause birth defects. It will prove a valuable reference work for clinicians, health councilors, teratologists, developmental biologists and risk assessors